KMID : 0620920200520010011
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Experimental & Molecular Medicine 2020 Volume.52 No. 1 p.11 ~ p.11
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The role of PDIA3 in myogenesis during muscle regeneration
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Wang Chao
Zhu Yuanjiao Wu Dan Wang Zien Xu Xiaoli Shi Yan Yang Gang Yu Yongming Peng Xi
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Abstract
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Beta 3 (¥â3) integrin plays an important role in the initiation of myogenesis in adult muscle. Protein disulfide isomerases (PDIs) can activate ¥â3 integrin in various cells to promote cell migration, adhesion and fusion. However, the effect of PDIs on myogenesis during muscle regeneration has not been elucidated. Here, we report that PDIA3 expression is induced in regenerating myofibers. The inhibition of PDIA3 in muscle injuries in mice disrupts myoblast differentiation, impairs muscle regeneration, and ultimately aggravates muscle damage. Moreover, PDIA3 expression is upregulated and observed on the cell surfaces of myoblasts during differentiation and fusion. The inhibition of extracellular PDIA3 with an anti-PDIA3 monoclonal antibody attenuates ¥â3 integrin/AKT/mTOR signal activity, inhibits myoblast differentiation, and blocks the fusion of myoblasts. Thus, PDIA3 may be a mediator of myoblast differentiation and fusion during muscle regeneration.
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KEYWORD
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Muscle stem cells, Stem-cell research
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